CD molecule is a cluster analysis method mainly used to identify monoclonal antibodies. The same differentiation antigen recognized by monoclonal antibodies from different laboratories is classified into a cluster of differentiation (CD).
The functions of CD molecules are mainly divided into the following aspects:
Participate in the mutual recognition of immune cells during the immune response;
Immune cells recognize antigen, activate, proliferate and differentiate; exert immune effect function;
Participate in the differentiation of hematopoietic cells and the regulation of hematopoietic process;
Participate in the occurrence of inflammation;
Participate in cell migration, such as tumor cell metastasis.
The two CD molecules mentioned today belong to the CD molecules involved in T cell recognition and activation.
1. [CD3E] Recombinant human T cell surface molecule CD3E, Fc tag (no animal origin)
Human CD3E protein, Fc tag (Animal-Free) #PRP2029
CD3E is a single-pass type I membrane glycoprotein on the surface of T cells. As part of the TCR-CD3 complex present on the surface of T lymphocytes, CD3E plays an important role in the adaptive immune response. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain, together with CD3-γ, CD3-δ and CD3-ζ and T cell receptor α/β and γ/δ heterodimers Forms T cell receptor-CD3 complex. The T cell receptor-CD3 complex plays an important role in coupling antigen recognition to a variety of intracellular signal transduction pathways, and is essential for the development and function of T cells. In addition, CD3E also plays an important role in the development of T cells, and CD3E gene defects can lead to severe immunodeficiency. The CD3E gene is also related to women's susceptibility to type I diabetes.
2. [CD28] Recombinant human T cell surface molecule CD28, Fc tag (no animal origin)
PRP2031 Human CD28 protein, Fc tag (Animal-Free) #PRP2031
The CD28 molecule is a member of the Ig superfamily and is expressed on the surface of CD4+ T cells and more than half of CD8+ T cells in the form of a homodimer composed of two peptide chains. CD28 molecule is an adhesion molecule on the surface of T cells, and it is also the most important co-stimulatory molecule. It can play a role in the B7-CD28 complex formed by non-covalent bonding with the ligand (B7) on the antigen-presenting cell (APC) Co-stimulation. The CD28 molecule plays a key role in many T cell processes, including cytoskeleton remodeling, cytokine production, survival and differentiation. Blocking the CD28/B7 interaction may help prevent harmful activation in allergic reactions and autoimmune diseases, and enhancing this interaction can promote tumor rejection. Therefore, CD28 and its signaling pathway may prove to be a useful target for the development of new treatments.
The above are the two CD molecules that are involved in T cell recognition and activation introduced today.
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The role of CD molecule in immune response mechanism: http://www.abbkine.cn/cd3e-protein